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Autoantibody test followed by CT imaging may reduce lung cancer mortality

By 1st November 2019No Comments

A combination of the EarlyCDT-Lung Test followed by CT imaging in patients at risk for lung cancer resulted in a significant decrease in late stage diagnosis of lung cancer and may decrease lung cancer specific mortality, according to research presented at the recent IASLC 2019 World Conference on Lung Cancer. The research was presented by Prof. Frank Sullivan, University of St Andrews, Scotland, UK.

Scotland has one of the highest rates of lung cancer in the world — approximately 460 men and 340 women for every 100,000 Scottish citizens are diagnosed with lung cancer every year. Fewer than 9 percent of all lung cancer patients reach their five-year survival mark.

The EarlyCDT-Lung Test is a novel autoantibody diagnostic test for the early detection of lung cancer that allows stratification of individuals according to their risk of developing lung cancer. The test identifies 41 percent of lung cancers with a high specificity of 90 percent, compared to CT scanning, which identifies 67 percent of lung cancers but with a low specificity of 49 percent. Sullivan and his team sought to determine whether using the EarlyCDT-Lung Test, followed by X-ray and CT scanning, could identify those at high risk of lung cancer.

They randomized 12,208 participants aged 50 to 75 who had a high risk of developing lung cancer over the next 24 months Test positive patients were offered a chest X-ray followed by a non-contrast thoracic CT scan. If the initial CT scan revealed no evidence of lung cancer then subsequent CT scans were offered 6 monthly for 24 months. Individuals with abnormalities were followed up over the study period or referred for clinical care as appropriate. Sullivan’s team discovered that 127 lung cancers were diagnosed in the study period (56 in the intervention group and 71 in the control arm) and 9.8 percent of the intervention group had a positive EarlyCDT-Lung test and 3.4 percent (n=18) of these were diagnosed with lung cancer in the study period.

Sullivan said that significantly fewer participants in the intervention group were diagnosed at a late-stage compared with the control group (33 vs 52).

Our results show that the combination of the EarlyCDT-Lung followed by CT imaging in those with a positive blood test, results in a significant decrease in late stage diagnosis of lung cancer and may decrease all cause and lung cancer specific mortality”.

https://tinyurl.com/Sullivan-at-IASLC