Skip to main content
News and Products

Fetal monitoring during high-risk pregnancies

By 30th October 2013No Comments

Few data exist for counseling and peri natal management of women after an ante natal diagnosis of early-onset fetal growth restriction. Yet, the consequences of preterm delivery and its attendant morbidity for both mother and baby are far reaching.  

A group of researchers known as the TRUFFLE group (Trial of Randomized Umbilical and Fetal Flow in Europe) are conducting a clinical trial to help determine the best timing of delivery in pre-term preg nancies complicated by poor fetal growth. Preliminary results from the trial have recently been published and demonstrated better than expected health outcomes in this high-risk group of fetuses (Lees et al., Peri- natal morbidity and mortality in early-onset fetal growth restriction: cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE) Ultrasound Obstet Gynecol. 2013 Oct;42(4):400-8).

Doctors are faced with a dilemma when deciding about the timing of the delivery of a baby who does not grow adequately as a fetus, i.e. fetal growth restriction. To deliver early potentially exposes the baby to risks associated with being born immature, but to deliver late risks allowing other serious problems to develop due to a lack of nourishment and oxygen in the womb. Doctors usually decide on the timing of delivery for a small baby in a high-risk pregnancy based on what they feel might be best for the baby, but with- out a solid basis in scientific facts. Research- ers designed a studyto try to help determine the best timing of delivery in pre-term preg nancies complicated by fetal growth restric tion. The study compared three groups of patients. In one group, the timing of delivery was based on monitoring the babys heart rate. In the other two groups, timing was based on changes in the Doppler ultrasound measurement of one of the babys blood ves sels.  A standardized prenatal monitoring and delivery protocol was used for all women in the trial. Ultimately, the investigators hope to determine which monitoring practice is best for safeguarding development by measuring babies neurological health at age two years. In the meantime, the researchers now report early results from TRUFFLE performed in 20 European centers. The analysis includes 503 women who were pregnant for less than 32 weeks and whose babies were smaller than would be expected. The results revealed bet- ter health outcomes for the babies compared with recent reports: deaths were uncommon (8%), and most of the babies (70%) survived without severe health problems.Women with hypertension were at increased risk of having babies who died before or after birth or who had health issues.

Although the effects of the different fetal monitoring practices on long-term neurode velopment are not yet known, these manage ment protocols would help effect a reduction in perinatal mortality and short term mor- bidity in pregnancies complicated by severe, early-onset fetal growth restriction,said lead investigator Chistoph Lees, MD of Queen Charlottes & Chelsea Hospital, London.

Dr. Lees noted that the two-year outcomes of the babies in the study will be available in 2014, which may provide clues about what management and monitoring strategy is best to optimize long term neurodevelopmental outcome.

http://tinyurl.com/Lees-et-al-paper