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Imaging of pain-associated processes in peripheral tissues

By 6th March 2014February 1st, 2019No Comments

By Dr M Peterson

Despite the significant effect chronic soft tissue pain such as tennis elbow can have on the sufferer, the basic pathophysiologic mechanisms underlying such pain are only very poorly understood. In addition, there are currently no  satisfactory methods for the precise localization of pain in peripheral tissues.

This article describes the basic  biochemistry of the Substance P – Neurokinin 1  (NK1) receptor system and summarizes the findings of a recent study using  a PET radioligand specific for the NK1 receptor to identify chronic pain.

The results show the potential of the approach, which should be confirmed by larger confirmatory studies.

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