A major challenge of 18F-fluoro-deoxyglucose positron emission tomography (FDG-PET) is the reliable detection of small lesions of less than 5-10 mm and the accurate measurement of an uptake value in such lesions. These issues can make the decision-making process for appropriate therapy and follow-up difficult. A recently published paper from the Isala Hospital in Zwolle, The Netherlands, describes a study whose aim was to determine the impact of a small-voxel reconstruction on the detectability of small lesions using a state-of-the-art TOF PET/CT device [1].
The results show that for small lesion detection with FDG-PET, in the vast majority of cases physicians prefer small 2 mm voxel image reconstruction in a system using time-of-flight technology, such as available on the Philips Ingenuity TF PET/CT.